Mark J Smyth Selected Research

Granzymes (Granzyme)

1/2015	CD4+ natural killer T cells potently augment aortic root atherosclerosis by perforin- and granzyme B-dependent cytotoxicity.
9/2013	Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors.
2/2013	The interaction between murine melanoma and the immune system reveals that prolonged responses predispose for autoimmunity.
7/2012	Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies.
6/2011	Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria.
8/2010	A role for granzyme M in TLR4-driven inflammation and endotoxicosis.
8/2010	Characterizing the anti-tumor function of adoptively transferred NK cells in vivo.
5/2010	Functional dissection of the granzyme family: cell death and inflammation.
11/2006	Perforin and granzymes have distinct roles in defensive immunity and immunopathology.
10/2005	KHYG-1, a model for the study of enhanced natural killer cell cytotoxicity.

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Mark J Smyth Research Topics

Disease

280	Neoplasms (Cancer) 01/2022 - 01/2002
69	Neoplasm Metastasis (Metastasis) 10/2020 - 02/2002
37	Melanoma (Melanoma, Malignant) 01/2022 - 11/2005
27	Breast Neoplasms (Breast Cancer) 01/2019 - 08/2004
22	Inflammation (Inflammations) 10/2020 - 12/2004
18	Lymphoma (Lymphomas) 10/2020 - 07/2002
18	Carcinogenesis 06/2014 - 08/2003
17	Infections 01/2018 - 02/2003
16	Carcinoma (Carcinomatosis) 06/2017 - 08/2002
13	Sarcoma (Soft Tissue Sarcoma) 01/2017 - 07/2002
12	Fibrosarcoma 01/2017 - 07/2002
10	Multiple Myeloma 01/2021 - 02/2011
9	B-Cell Lymphoma (Lymphoma, B Cell) 10/2020 - 03/2004
9	Leukemia 01/2018 - 09/2004
6	Renal Cell Carcinoma (Grawitz Tumor) 12/2019 - 12/2007
6	Graft vs Host Disease (Graft-Versus-Host Disease) 02/2017 - 11/2005
5	Autoimmune Diseases (Autoimmune Disease) 12/2007 - 08/2003
4	Hematologic Neoplasms (Hematological Malignancy) 12/2020 - 03/2011
4	Osteosarcoma (Osteogenic Sarcoma) 11/2019 - 11/2012
4	Adenocarcinoma 01/2018 - 06/2007
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2018 - 07/2009
4	Virus Diseases (Viral Diseases) 01/2016 - 02/2003
4	Kidney Neoplasms (Kidney Cancer) 04/2010 - 04/2002
3	Chronic Disease (Chronic Diseases) 10/2020 - 04/2013
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2019 - 01/2018
3	Disease Progression 01/2019 - 01/2016
3	Colonic Neoplasms (Colon Cancer) 01/2018 - 04/2011

Drug/Important Bio-Agent (IBA)

59	CytokinesIBA 01/2021 - 02/2002
39	LigandsIBA 10/2020 - 01/2002
37	PerforinIBA 01/2015 - 01/2002
36	Monoclonal AntibodiesIBA 01/2022 - 01/2002
25	AntigensIBA 10/2020 - 11/2002
23	Immune Checkpoint InhibitorsIBA 01/2022 - 01/2014
22	Interleukin-12 (IL 12)IBA 11/2019 - 02/2002
21	AntibodiesIBA 01/2020 - 01/2003
20	MethylcholanthreneIBA 06/2017 - 01/2002
18	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2020 - 01/2002
17	Proteins (Proteins, Gene)FDA Link 12/2020 - 05/2002
15	interleukin-21 (interleukin 21)IBA 01/2016 - 02/2004
14	InterferonsIBA 11/2020 - 01/2002
14	Adenosine (Adenocard)FDA LinkGeneric 10/2020 - 01/2010
14	CarcinogensIBA 06/2017 - 01/2002
14	alpha-galactosylceramideIBA 01/2013 - 02/2002
13	Granzymes (Granzyme)IBA 01/2015 - 05/2003
11	Interferon-gamma (Interferon, gamma)IBA 01/2021 - 01/2002
11	InterleukinsIBA 01/2021 - 07/2002
11	Interleukin-17 (Interleukin 17)IBA 01/2019 - 03/2010
9	Interleukin-2 (IL2)IBA 01/2020 - 06/2005
9	VaccinesIBA 05/2017 - 04/2008
9	AnthracyclinesIBA 11/2014 - 10/2009
9	TNF-Related Apoptosis-Inducing LigandIBA 10/2008 - 02/2002
8	Adenosine Triphosphate (ATP)IBA 01/2021 - 05/2002
8	EnzymesIBA 10/2020 - 01/2003
8	Trastuzumab (Herceptin)FDA Link 01/2019 - 08/2004
8	Purinergic P1 Receptors (Adenosine Receptor)IBA 12/2017 - 01/2010
7	Therapeutic UsesIBA 01/2022 - 08/2005
7	Interleukin-23 (Interleukin 23)IBA 01/2018 - 05/2010
7	ChemokinesIBA 11/2014 - 04/2007
6	Interleukin-18 (Interleukin 18)IBA 01/2020 - 02/2002
6	Interferon Type IIBA 01/2020 - 07/2005
6	Fc Receptors (Fc Receptor)IBA 10/2017 - 02/2004
6	T-Cell Antigen Receptors (T-Cell Receptor)IBA 08/2015 - 07/2002
6	Neoplasm Antigens (Tumor Antigens)IBA 04/2013 - 01/2006
6	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 05/2010 - 02/2004
5	Pharmaceutical PreparationsIBA 01/2021 - 05/2002
5	Interleukin-15 (Interleukin 15)IBA 10/2020 - 04/2008
5	InflammasomesIBA 12/2019 - 10/2009
5	IpilimumabIBA 10/2019 - 02/2015
5	Antiviral Agents (Antivirals)IBA 01/2017 - 02/2003
5	Interleukin-4 (Interleukin 4)IBA 01/2015 - 02/2002
5	Fas Ligand Protein (Fas Ligand)IBA 03/2014 - 02/2002
5	Death Domain ReceptorsIBA 11/2011 - 01/2003
4	Neutralizing AntibodiesIBA 11/2019 - 06/2013
4	Natural Killer Cell ReceptorsIBA 01/2018 - 01/2009
4	Interleukin-10 (Interleukin 10)IBA 01/2018 - 12/2011
4	AutoantigensIBA 05/2017 - 11/2002
4	Biomarkers (Surrogate Marker)IBA 01/2017 - 04/2014
4	Histone Deacetylase InhibitorsIBA 01/2017 - 08/2008
4	Galactosylceramides (Galactocerebrosides)IBA 12/2013 - 04/2012
4	Doxorubicin (Adriamycin)FDA LinkGeneric 07/2013 - 08/2004
4	NK Cell Lectin-Like Receptor Subfamily KIBA 08/2006 - 11/2002
3	Interleukin-6 (Interleukin 6)IBA 11/2020 - 12/2013
3	Immunoglobulins (Immunoglobulin)IBA 10/2020 - 04/2013
3	NectinsIBA 10/2020 - 04/2012
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2020 - 01/2017
3	Transcription Factors (Transcription Factor)IBA 01/2020 - 02/2011
3	EpitopesIBA 01/2020 - 01/2016
3	Denosumab FDA Link 12/2019 - 01/2018
3	pembrolizumabIBA 01/2019 - 01/2017
3	Programmed Cell Death 1 ReceptorIBA 01/2019 - 12/2017
3	Immunoglobulin G (IgG)IBA 10/2017 - 06/2013
3	Chemokine ReceptorsIBA 05/2017 - 01/2009

Therapy/Procedure

121	Therapeutics 01/2021 - 11/2002
105	Immunotherapy 01/2022 - 04/2002
20	Drug Therapy (Chemotherapy) 01/2018 - 01/2007
7	Ligation 05/2015 - 05/2002
6	Stem Cell Transplantation 12/2020 - 11/2005
4	Transplantation 01/2019 - 12/2007
4	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2018 - 01/2003
4	Radiotherapy 12/2012 - 01/2007